GLP-1 Medication Comparison: Ozempic vs Wegovy vs Mounjaro vs Zepbound
A side-by-side comparison of the major GLP-1 medications: molecule, dosing, cost, FDA indication, side effects, and average weight loss. Pick the right one for your situation.
GLP-1 Medications
Plain-English guides to Ozempic, Wegovy, Mounjaro, Zepbound, Saxenda, and the science behind GLP-1 receptor agonists.
Microdosing GLP-1: The Trend, the Reality, and What the Data Shows
Some patients use sub-therapeutic GLP-1 doses for "metabolic optimization" or maintenance. Here is what microdosing actually means, who it might help, and what to be skeptical of.
Rybelsus: The Oral Semaglutide Pill — How It Compares to Injectable
Rybelsus is oral semaglutide — the same molecule as Ozempic and Wegovy in pill form. Less effective than injectable, but easier to take. Here is what to know.
GLP-1 Cost and Insurance Coverage: How to Actually Get These Drugs Covered
Out-of-pocket costs for GLP-1 medications can run $1,000+ per month. Here is the playbook for insurance coverage, manufacturer programs, and managing prior authorizations.
GLP-1 Medications and Type 2 Diabetes: How They Lower Blood Sugar
GLP-1 drugs were designed to lower blood sugar before they became weight-loss famous. Here's how they work in diabetes, what to expect for HbA1c, and what changes when you also lose weight.
Compounded GLP-1: What It Is, Why It Exists, and Whether to Trust It
Compounded semaglutide and tirzepatide became widely available during shortages. The FDA has tightened rules. Here's how compounding works, the risks, and what to look for.
Saxenda (Liraglutide): The Daily-Injection GLP-1 That Started It All
Saxenda was the first GLP-1 approved for weight loss. It is daily, less effective than semaglutide and tirzepatide, but still has a role for some patients. Here's what you need to know.
Zepbound vs Mounjaro: When the Same Drug Has Two Brand Names
Zepbound and Mounjaro are both tirzepatide. The differences are FDA labeling, insurance coverage, and which population they were studied in. Here's the practical breakdown.
Mounjaro (Tirzepatide): The Dual-Action GLP-1 That Changed the Game
Mounjaro is tirzepatide — a dual GIP/GLP-1 receptor agonist that consistently outperforms semaglutide in trials. Here's how it works, dosing, side effects, and what to expect.
Wegovy vs Ozempic: Same Molecule, Different Label — What Actually Differs
Wegovy and Ozempic are both semaglutide. The differences come down to dose, FDA indication, insurance coverage, and the patient population studied. Here's what you need to know.
Ozempic for Weight Loss: A Practical Guide for People Who Want to Keep Their Muscle
Everything you need to know about Ozempic for weight loss — how semaglutide works, realistic timelines, side effects, dosing, and how to avoid losing muscle while you lose fat.